Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/MTLR/G15 Stable Cell L
The motilin receptor (MTLR) represents a clinically useful pharmacological target as agonists binding to the MTLR have gastroprokinetic properties Motilin is a 22 amino acid peptide that potently stimulates gastrointestinal contractility The biological effects of motilin are mediated by a G sub q /sub -coupled seven transmembrane protein currently termed motilin receptor (MR) that shares significant sequence similarity with the ghrelin receptor The motilin receptor is also activated by the antibiotic erythromycin this interaction appears to mediate some of the gastrointestinal side effects of erythromycin Although motilides (non-antibiotic derivatives of erythromycin) such as ABT-229 have been investigated for treatment of diabetic gastroporesis the effectiveness has been limited by tachyphylaxis (decreased response to ligand) resulting from receptor downregulation Agonists of the motilin receptor with reduced densensitization activity remain a potential treatment for dis
Genscript Corporation CHO-K1/B7-H3 Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human CD276 (B7-H3) on the surface The surface expression of B7-H3 is validated by FACS analysis This cell line is recommended for cell-based binding assay to screen antibodies against B7-H3 or to measure binding affinity between B7-H3 and anti-B7-H3 antibodies
Cell Biologics Aged Mouse Brain Microvascular Endothelial Cells
Aged Mouse Brain Microvascular Endothelial Cells
Genscript Corporation CHO-K1/SST2/G15 Stable Cell L
Recombinant CHO-K1 cells stably overexpress human somatostatin receptor 2 (SST2) on the surface and contain high levels of G protein G i to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/CD64 Stable Cell Line
Recombinant CHO-K1 cells stably overexpress high affinity human Fc fragment of IgG receptor Ia (Fc RI CD64) on the cell surface containing one alpha chain and two gamma chains The surface expression of CD64 is validated by FACS analysis This stable cell line product is designed for measuring the binding affinity and stability of the Fc region of antibodies Fc fusion proteins or antibody based biologics that bind with CD64 during biologics research and development
Amsbio LLC HEK293-KCNN4 cell line with RFP and Puromycin dual marker
HEK293-KCNN4 cell line with RFP and Puromycin dual marker
Genscript Corporation CHO-K1/CD16B NA1 Stable Cell L
Recombinant CHO-K1 cells stably overexpress human Fc fragment of IgG receptor IIIb (Fc RIIIb/CD16B NA1) The surface expression of CD16B NA1 is validated by FACS analysis This stable cell line product is designed for measuring binding affinity and stability of Fc region of antibodies Fc fusion proteins or antibody based biologics that bind with CD16B during biologics research and development
Genscript Corporation CHO-K1/CXCR4/G15 Stable Cell
CXCR4 is a receptor for the C-X-C chemokine SDF-1 (Stromal Cell-Derived Factor 1) It is involved in haematopoiesis and cardiac ventricular septum formation and plays an essential role in vascularization of the gastrointestinal tract cerebellar development and survival of hippocampal-neuron of central nerve system CXCR4 also acts as a primary receptor for some HIV-2 isolates and as a co-receptor with CD4 for HIV-1 X4 viruses